At that time, he was also actively involved in defining how to best measure and use CKMB to determine the diagnosis and prognosis (infarct size) of patients with acute myocardial infarction. High-sensitivity cardiac troponin (hs-cTn) assays detect troponin concentrations in the ng/L range. Quality Assessment of Included Studies Methods and results Objective: Vasopressin increases water permeability and activity of the epithelial sodium channel ENaC in the distal nephron of the kidney, favoring increased water and sodium retention. Methods: A noninvasive, rapid, broadly available, home-based test to detect hs-cTn increases would facilitate risk-stratification. Endogenous opioids, enkephalins, are known to increase with acute kidney injury. Vol. We aimed to directly compare preoperative high-sensitivity cardiac troponin (hs-cTn) I and T concentration for the prediction of major cardiac complications after non-cardiac surgery. Review this investigator's areas of expertise, accomplishments, grants and outputs on Pure Experts. Sections for Allan S. Jaffe, M.D. Objectives 2020 Dec 19 [Epub ahead of print] View PubMed; Vallabhajosyula S, Verghese D, Subramaniam AV, … Adult (>18 years) AMI admissions using the National Inpatient Sample database (2000–2017) were evaluated for in‐hospital AIS. Describes the nature of a clinical study. author = "Johannes Mair and Allan Jaffe and Fred Apple and Bertil Lindahl", PMID: 29331273 The use of cardiac biomarkers is expanding rapidly as patients and physicians look for more objective ways to diagnose and monitor patients. We sought to describe the temporal changes in comorbidities, illness severity, diagnoses, procedures and adjusted mortality within our CICU practice in recent years. In this small pilot study (n=18) among patients with cardiac risk undergoing non-cardiac surgery, we determined if high-sensitivity cardiac troponin I (hscTnI) changes b... Background: Outcomes of interest included in‐hospital mortality,... Background Elevations of ceramides are predictive of cardiovascular mortality. Moritz Biener, Matthias Mueller, Mehrshad Vafaie, Allan S Jaffe, Christian Widera, Hugo A Katus, and Evangelos Giannitsis. The sophistication of these assays and their sensitivity is increasing amplifying these challenges since small changes may be of importance. Methods... Background Since my... Background: High-sensitivity cardiac troponin (hs-cTn) assays quantify cTn in patients at very low concentrations. The purpose of this study was to evaluate baseline hs-cTnT and CAC in relation to ASCVD. AACC Academy Award for Outstanding Contributions to Clinical Chemistry in a Selected Area of Research. Subfractionation of LDL according to... Background: A noninvasive, rapid, home-based test to exclude acute myocardial injury at the time of the test and for the next 7 hours would help manage patients with suspected myocardial infarction. “Myocardial injury is quite common in patients with COVID. Objective Direct Phone (507) ***-**** Get Email Address Get Phone Number. Cardiology Today | Allan S. Jaffe, MD, has spent several decades exploring and advancing the clinical utility of biomarkers and has traveled … 3. Biochem. We thus conducted a systematic review and meta‐analysis to improve ou... Table S1. However, there are no publications discussing the extent of biotin use or plasma concentrations observed among the patient population. Methods This was a retros... Introduction Cons-Cardiology at Mayo Clinic. As with any MI subtype, there must be clinical evidence of myocardial ischemia … To evaluate sex-specific disparities in acute kidney injury (AKI) complicating acute myocardial infarction-related cardiogenic shock (AMI-CS) in the United States. The primary endpoint was... Background: Methods Dr. Allan Jaffe is a graduate of the University of Maryland School of Medicine. There are limited contemporary data prevalence and outcomes of acute ischemic stroke (AIS) complicating acute myocardial infarction (AMI). Circulation 2004;110:104–6. Division of Cardiovascular Diseases and Department of Laboratory Medicine and Pathology Mayo Clinic College of Medicine Mayo Clinic 200 First Street SW, Room 16th Floor Rochester, MN 55905, USA email: jaffe.allan@mayo.edu Received: February 14, 2006 Accepted with revision: March 24, 2006. In order to manage risks of bleeding and thrombosis after some surgical procedures, platelet function is often measured repeatedly over days or weeks using laboratory tests of platelet function. Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN 55905, USA. His efforts have since focused on the measurement of cardiac troponin and how to use the value obtained from clinical studies. 2019 Oct;94(10):e117-e121. American Heart Association; Heart … This study sought to assess the contemporary outcomes of patients transferred after receiving fibrinolytic therapy (‘drip-and-ship’) for ST-segment elevation myocardial infarction (STEMI) in the United States. Dr. Allan Jaffe, MD is a cardiologist in Rochester, Minnesota. Having more than 48 years of diverse experiences, especially in CARDIOVASCULAR DISEASE (CARDIOLOGY), Dr. Allan S Jaffe affiliates with many hospitals including Mayo Clinic Hospital Rochester, Mayo … We evaluated the effectiveness of a nationwide implementation of clinical pathway... Background: His specialties include Cardiovascular Disease, Internal Medicine, Radiology. of publications stored in Pure and citations from Scopus; 1974 … 2020. Tel: +1 507 284‐1648, Email: jaffe.allan@mayo… Founding member/ past President and Chief Medical Officer of the Accreditation Management Board of the American College of Cardiology … However, it remains to be determined how to diagnose, risk stratify and treat patients with T2MI. Saraschandra Vallabhajosyula, Department of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905. Access Allan's Contact Information . Read ratings and reviews from other patients. We sought to verify the utility of plasma c... Background: Dr. Jaffe's initial efforts focused on coagulation and fibrinolysis and resulted in an appreciation for the pro-coagulant effects of plasminogen activators. We compared rates of analytical outliers, and percent of emergency department (ED) patients with cardiac troponin (cTn) values above the 99th percentile upper reference limit (URL), for two conventional and one high sensitivity cTn assay. Allan Jaffe, M.D., Consultant and Chair of Mayo Clinic’s Division of Clinical Core Laboratory Services, with a joint appointment in the Division of Cardiovascular Diseases, will be presenting a webinar on the implementation of a high-sensitivity troponin I assay. Objectives: Sex-specific 99th percentiles derived from the AACC Universal Sample Bank for the Roche Gen 5 cTnT assay: comorbidities and statistical methods influence derivation of reference limits. hs-cTn assays have higher analytic precision... Cardiac troponin (cTn) testing has evolved significantly in recent times. Methods: Ceramides are sphingolipids involved with cellular signaling. Methods: 2010;56:254-261. To determine the utility of the serum free light chain (FLC) assay for routine screening of light chain amyloidosis (AL) in patients with heart failure. Dr. Jaffe has eight offices in Minnesota and Wisconsin where he specializes in Internal Medicine and Cardiology. Location. J Am Coll Cardiol 2013;61:1753–8. Aortic valve stenosis (AS) results in significant cardiovascular morbidity and mortality. Figure S1. Adult (>18 years) STEMI admissions were identified using the National Inpatient Sample databa... Ceramides are bioactive lipids that act as secondary messengers for both intra- and inter-cellular signaling. Dr. Jaffe is affiliated with Essentia Health Saint Marys Medical Center, Mayo Clinic Health System Mankato, Fairview Southdale Hospital, Mayo … Allan S. Jaffe, MD. Mayo Clinic Health System - Franciscan Medical Cen 800 W Ave S, La Crosse, Wisconsin 54601 • (507) 284-2511 Circulation. High-sensitivity cardiac troponin testing was recommended, as these assays have improved precision at low concentrations, but concerns over specificity may have limited implementation. Allan Jaffe, MD: Mayo Clinic: Chair of the Division of Clinical Core Laboratory Services in the Department of Laboratory Medicine and Pathology: Frank Peacock, MD: Baylor College of Medicine: Associate Chair of Emergency Medicine. As a task force, we have previously p... Background: Analytical validation of a high-sensitivity cardiac troponin T assay. Methods: We prospectiv... Background: To assess the influence of insurance status on STEMI outcomes. Acute myocardial infarction (MI) can occur from increased myocardial oxygen demand and/or reduced supply in the absence of acute atherothrombotic plaque disruption; a condition called type 2 myocardial infarction (T2MI). Methods: Despite being frequently encountered in clinical practice, the population-based incidence and trends remain unknown and the long-term outcomes incompletely characterized. 200 1st St SW, Rochester, Minnesota, 55905, United States. Share . E-mail address: jaffe.allan@mayo.edu. © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). (2)Advisor to residents and Consultant in Cardiovascular Diseases, Mayo … Allan Jaffe, M.D., Consultant and Chair of Mayo Clinic’s Division of Clinical Core Laboratory Services, with a joint appointment in the Division of Cardiovascular Diseases, and Loralie Langman, Ph.D., Consultant in the Department of Laboratory Medicine and Pathology at Mayo, were recipients of this year's honors. 2. Publications. Mayo Clinic, Rochester (United States of America) Speciality : Acute Coronary Syndromes 8 presentations Has spent career working on biomarkers of cardiac injury, thrombosis and hemodynamic stress. Dr. Jaffe often sees individuals for … Prior studies have demonstrated that the cardiac intensive care unit (CICU) patient population has evolved over time. There are limited data on how sex influences the outcomes of acute myocardial infarction-cardiogenic shock (AMI-CS) in young adults. This study sought to examine the in-hospital mortality, temporal trends and resource utilization in early vs. delayed IHCA in STE... Background: Allan S. Jaffe, MD, Department of Cardiovascular Diseases, Gonda 5, Mayo Clinic, 200 First St SW, Rochester, MN 55905. The universal definition of myocardial infarction (UDMI) standardizes the approach to the diagnosis and management of myocardial infarction. Research output per year. A single copy of these materials may be reprinted for noncommercial personal use only. Biochem. Elevated plasma concentrations of ceramides are associated with multiple risk factors of atherosclerotic cardiovascular diseases and comorbidities including obesity, insulin resistance and diabetes mellitus. Comment on JACC Heart Fail. Adult admissions with AMI-CS with IHDs were identified using the National Inpatient Sample (2000-2016) and were classified as early (≤2 days), mid-term (3-7 days), and late... Increases in cardiac troponin (cTn) indicative of myocardial injury are common in patients with COVID-19 and associated with adverse outcomes such as arrhythmias and death. “This consortium of hospitals have added substantially to our knowledge of … Setting: Due to our privacy policy, only current members can send messages to people on ResearchGate. Yader Sandoval 1 , Allan S Jaffe 2 Affiliations 1 Department of ... Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minn. Electronic address: jaffe.allan@mayo.edu. Despite major advances in acute treatment using network approaches to allocate patients to timely reperfusion and optimal antithrombotic treatment, patients remain at high risk for thrombotic complications. Background: Low values of high-sensitivity cardiac troponin (hs-cTn) and coronary artery calcium (CAC) scores of zero are associated with a low risk for atherosclerotic cardiovascular disease (ASCVD). International recommendations on high-sensitivity cardiac troponin (hs-cTn) testing recommend that laboratories select only one sample type for testing. University students and faculty, institute members, and independent researchers, Technology or product developers, R&D specialists, and government or NGO employees in scientific roles, Health care professionals, including clinical researchers, Journalists, citizen scientists, or anyone interested in reading and discovering research. Methods: Dr. Allan Jaffe M.D. Allan Jaffe first saw the play in 1965, during a painful breakup with a girlfriend. Allan S. Jaffe, MD, Department of Cardiovascular Diseases, Gonda 5, Mayo Clinic, 200 First St SW, Rochester, MN 55905. PMID: 28843652 DOI: 10.1016/j.amjmed.2017.07.033 Abstract The recent approval of the fifth-generation cardiac troponin T assay, which has characteristics clinically of a high-sensitivity … Analytical outliers occur with most troponin assays and can adversely affect patient management. It is unclear if cardiac troponin values are stable in patients prior to undergoing non-cardiac surgery, or if they tend to rise towards the day of surgery. Our objective was to … Mayo Clinic Health System - Franciscan Medical Cen 800 W Ave S, La Crosse, Wisconsin 54601 • (507) 284-2511 Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota. He received his house staff and Cardiology training at Washington University and continued there for 22 years rising to the rank of Professor of Medicine and Director of the Coronary Care Unit. Dr. Jaffe is professor of medicine at the Mayo Clinic College of Medicine and Science in Rochester, Minn. As a single variable, it has only modest diagnostic accuracy for acute myocardial infarction. Extracorporeal membrane oxygenation (ECMO) is increasingly used in acute myocardial infarction (AMI); however, there are limited large-scale national data. To guide patient stratification and treatment in AS, echocardiographically defined cardiac damage classes have been proposed. Allan S Jaffe is a doctor primarily located in Rochester, MN, with another office in Rochester, MN. AACC Academy Award for Outstanding Contributions to Clinical Chemistry in a Selected Area of Research. Thygesen K, Alpert JS, Jaffe AS, et al. But he pointed out that … That’s the message from a review by Yader Sandoval, MD, and Allan Jaffe, MD (both Mayo Clinic, Rochester, MN), along with James Januzzi Jr, MD (Massachusetts General Hospital, Boston). Methods: Irrespective of the underlying condition, cTn elevati... Background: Fourth Universal Definition of Myocardial Infarction: Will it change how we practice emergency medicine? His credentials are: M.D. The webinar will be held February 13 from 1:00-2:00 p.m. eastern. Allan Jaffe. Should myocardial infarction type 2 be regarded as two separate entities? How is cardiac troponin released from injured myocardium? The recent introduction of high‐sensitivity cardiac troponin (hs‐cTn) assays has allowed clinicians to measure hs‐cTn before and after cardiac stress testing, but the hs‐cTn release pattern and potential utility in identifying inducible myocardial ischemia are unclear. Methods: * Consultant and Professor of Cardiology & Laboratory Medicine and Pathology Chair, CCLS Division, Department of Laboratory Medicine and Pathology Mayo Clinic and Medical School Rochester, Minnesota *Dr. Jaffe is or has been a consultant to most of the major diagnostic companies as well as Novartis. HQ Phone (507) 284-2511. He holds the academic rank of professor of laboratory medicine and pathology and also professor of medicine. A retrospective cohort of AMI‐CS admissions using the National Inpatient Sample (2000–2014) was identified. Our goal was to evaluate the comparability of the Siemens ADVIA Centaur hs-cTnI assay across different matrices and under different storage conditions. There are limited data on acute kidney injury (AKI) complicating acute myocardial infarction with cardiogenic shock (AMI-CS). Jaffe AS(1), Miller WL(2). Using the National Inpatient Sample from 2000 to 2016, we identified adults with a primary diagnosis of AMI and concomitant CS admitted to the United States census regions of Northeast, Mid... Background: Type 2 myocardial infarction (T2MI) occurs due to an acute imbalance in myocardial oxygen supply and demand in the absence of athero-thrombosis. https://www.mayo.edu › research › faculty › jaffe-allan-s-m-d › bio-00027772 Allan Jaffe Contact Information. This was a retrospective cohort study from 2000 to 2014 from the National Inpatient Sample (20% sample of all hospitals in the United States). Jaffe AS, Katus H. Acute coronary syndrome biomarkersdthe need for more adequate reporting. Corrigendum to "Measuring the contribution of Lp(a) cholesterol towards LDL-C interpretation" [Clin. She had a history of... Open in new tabDownload slide Allan S Jaffe, MD. Dr. Jaffe graduated from the University of Maryland School of Medicine,University of Maryland School of Medicine in 1972. Since the mature pentapeptides are unstable, we evaluated the performance of an assay that measures proenkephalin 119-159 (PENK), a stable peptide formed concomitantly with mature enkephalins. Preparing the United States for high-sensitivity cardiac troponin assays. Subsequently, with investigators at Washington University, he helped to develop and was responsible for the validation studies of the first cardiac troponin I assay. Lipoprotein(a) [Lp(a)] is a pro-atherogenic and pro-thrombotic LDL-like particle recognized as an independent risk factor for cardiovascular disease (CVD). Letter by Sandoval et al Regarding Article, “Designing a Better Mousetrap: Reflections on the November 28, 2017, US Food and Drug Administration Meeting on Next-Generation “High-Sensitivity” Cardiac Troponin Assays to Diagnose Myocardial Infarction”, Sample matrix and high-sensitivity cardiac troponin I assays, Global Adoption of High-Sensitivity Cardiac Troponins and the Universal Definition of Myocardial Infarction, Staging systems use for risk stratification of systemic amyloidosis in the era of high-sensitivity troponin T assay, Between-day versus within-day imprecision using the Abbott high-sensitivity cardiac troponin I assay at concentrations around 5 ng/l, High-sensitivity cardiac troponin T increases after stress echocardiography, Fourth universal definition of myocardial infarction (2018), Cardiac troponin and natriuretic peptide analytical interferences from hemolysis and biotin: Educational aids from the IFCC Committee on Cardiac Biomarkers (IFCC C-CB), Evaluation of the Siemens ADVIA Centaur high-sensitivity cardiac troponin I assay in serum, 1-h High-Sensitivity Troponin Rule-Out and Rule-In Approach, Fourth Universal Definition of Myocardial Infarction (2018), Possible mechanisms behind cardiac troponin elevations, Comparison of high-sensitivity cardiac troponin I and T for the prediction of cardiac complications after non-cardiac surgery, Prevalence of biotin supplement usage in outpatients and plasma biotin concentrations in patients presenting to the emergency department, Plasma Ceramides: A Novel Predictor of Major Adverse Cardiovascular Events After Coronary Angiography, Lipoprotein(a) Cholesterol But Not Lipoprotein(a) Mass is Significantly Correlated with Angiographic Coronary Artery Disease and Major Adverse Events, Detectable High-Sensitivity Cardiac Troponin within the Population Reference Interval Conveys High 5-Year Cardiovascular Risk: An Observational Study, Analytical performance of an immunoassay to measure proenkephalin, Clarifying the Proper Definitions for Type 2 Myocardial Infarction, The prognostic impact of periprocedural myocardial infarction and injury, Clinical Laboratory Practice Recommendations for the Use of Cardiac Troponin in Acute Coronary Syndrome: Expert Opinion from the Academy of the American Association for Clinical Chemistry and the Task Force on Clinical Applications of Cardiac Bio-Markers of the International Federation of Clinical Chemistry and Laboratory Medicine. He has 48 years of experience. The IFCC Committee on Clinical Applications of Cardiac Bio-Markers (C-CB) has directives and initiatives focused on providing evidence-based educational resources to aid and improve understanding around key analytical and clinical aspects of cardiac biomarkers used in clinical practice and the research setting. Management and outcomes of uncomplicated ST-segment elevation myocardial infarction patients transferred after fibrinolytic therapy, Influence of Human Immunodeficiency Virus Infection on the Management and Outcomes of Acute Myocardial Infarction With Cardiogenic Shock, Epidemiological Trends in the Timing of In-Hospital Death in Acute Myocardial Infarction-Cardiogenic Shock in the United States, Cardiac Troponin for the Diagnosis and Risk-Stratification of Myocardial Injury in COVID-19: JACC Review Topic of the Week, Atherosclerotic Cardiovascular Disease Risk Stratification Based on Measurements of Troponin and Coronary Artery Calcium, Implementing High-Sensitivity Cardiac Troponin T in a US Regional Healthcare System, Weekend Effect in the Management and Outcomes of Acute Myocardial Infarction in the United States, 2000-2016, The Universal Definition of Myocardial Infarction: Present and Future, Pulmonary artery catheter use in acute myocardial infarction-cardiogenic shock: Pulmonary artery catheters in AMI-CS, ST-segment Elevation, Myocardial Injury, and Suspected or Confirmed COVID-19 Patients: Diagnostic and Treatment Uncertainties, Acute Myocardial Infarction Due to Fixed Coronary Artery Stenosis From Myocardial Bridging, Our nearly complete diagnostic trip of thousands of steps begets a new trip therapeutically, Complications in Patients with Acute Myocardial Infarction Supported with Extracorporeal Membrane Oxygenation, The Gloomy Long-Term Prognosis of Patients With Type 2 Myocardial Infarction or Myocardial Injury, HIGH SENSITIVITY CARDIAC TROPONIN: NOT JUST HEART DISEASE, Natriuretic Peptides to Predict Short-Term Mortality in Patients With Sepsis: A Systematic Review and Meta-analysis, Regional Variation in the Management and Outcomes of Acute Myocardial Infarction With Cardiogenic Shock in the United States, Incidence, Trends and Outcomes of Type 2 Myocardial Infarction in a Community Cohort, Extracorporeal Membrane Oxygenation Use in Acute Myocardial Infarction in the United States, 2000 to 2014, Early vs. delayed in-hospital cardiac arrest complicating ST-elevation myocardial infarction receiving primary percutaneous coronary intervention, Use of troponins in clinical practice: Evidence in favour of use of troponins in clinical practice, Estimating Short- and Long-term Reference Change Values and Index of Individuality for Tests of Platelet Function, Temporal trends, predictors, and outcomes of acute kidney injury and hemodialysis use in acute myocardial infarction-related cardiogenic shock, Real-Time Detection of Analytical Outliers on the Roche Troponin T Generation 5 Assay, Educational Recommendations on Selected Analytical and Clinical Aspects of Natriuretic Peptides with a Focus on Heart Failure: A Report from the IFCC Committee on Clinical Applications of Cardiac Bio-Markers, Acute respiratory failure and mechanical ventilation in cardiogenic shock complicating acute myocardial infarction in the USA, 2000–2014, Sex disparities in acute kidney injury complicating acute myocardial infarction with cardiogenic shock. 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