It didn't work for me which is a shame because it was much less expensive than Provigil. When I did go to work, no one noticed how different I was or how much I was struggling. I found out today my insurance doesn't find value in occupational therapy - who else is going to give me tips on energy conservation, effective exercises for MS and more? I take it in the morning but can easily nap/sleep. I think irritated is probably my … For one of the most prevalent symptoms of MS, fatigue, methylphenidate, modafinil, and amantadine are commonly prescribed. It’s hard to explain simply wanting to be engaged with your own life to someone who has never had that taken from them long term. Evaluating the effects of amantadine, modafinil and acetyl-L-carnitine on fatigue in multiple sclerosis – result of a pilot randomized, blind study. I just want to sleep, FOCUS when I’m awake and feel good in those waking hours. My wife has been on Amantadine for a couple of months now. In this case it is building up the tolerance to the drug and have been asked to keep it up for another few weeks but reduce the dosage to help with the sleep issues. I wrote my neuro asking if i should just take it 1x a day instead of twice. I was hoping that the amantadine would help with the fatigue and give me some focus. has this happened to anyone else&what have you done,if there is anything? P.s. My neuro said it was an energy pill (not) but it does help me focus. The effects of amantadine from one randomised, double-blind, placebo-controlled, cross-over trial comparing amantadine with placebo for the treatment of fatigue in 80 people with Guillain-Barré syndrome (GBS) were uncertain for the proportion of people achieving a favourable outcome six weeks post-intervention (odds ratio (OR) 0.56 (95% confidence interval (CI) 0.22 to 1.35, N = 74, P = 0.16). It has been demonstrated that this medication, through some unknown mechanism, is sometimes effective in relieving fatigue in multiple sclerosis. Food as medicine and other coping skills too. Just projects/work doesn't always give you more time. I think if i just had some basic work, personal projects like the groceries and taking care of the kids - id be good. My neurologist has just changed me from Tecfidera to a new drug, Mayzent. I do better with more sleep. In the randomised crossover TRIUMPHANT-MS trial, none of these 3 agents was superior to placebo in improving MS-related fatigue, but they did cause more adverse … We haven't gotten to that point yet (I don't think), but it's nice to know it's an option. Keep looking, it might be a combo of things that you just have not tried yet. I still have my caffeine in the morning, but it’s less than it use to be, and a that’s work in progress. Amantadine Canada. Amantadine Therapy for Fatigue in Multiple Sclerosis T.J. Murray ABSTRACT: We carried out a double blind control study of fatigue in 32 patients with multiple sclerosis, comparing amantadine hydrochloride 100 mg twice a day and placebo. This turned into a lack of focus and more fatigue and experimentation with some caffeine tablets (I barely drink soda/no coffee). I know I have been forcing myself to do more, and a million times a day I feel I HAVE to sit down. To have it back?! Hello, anyone else in a similar situation. When EC-Naprosyn was provided as a single dose with antacid (54 mEq buffering capability), the top plasma levels of naproxen were unchanged, but the moment to peak was lessened (indicate Tmax fasted 5.6 hours, suggest Tmax with antacid 5 hrs), although not considerably. She says they go away after a while but what died that mean?!?! At last someone who does not think that it cant be a problem as I am retired! I didn’t have headaches with it, but the other drugs for fatigue gave me migraines. Wondering if anyone has experience with this drug? Substantial evidence supporting their efficacy is lacking, however. But you can’t live like that so neuro started me on amantadine and I’ve had some of the worst headaches daily. New comments cannot be posted and votes cannot be cast, More posts from the MultipleSclerosis community. Looks like you're using new Reddit on an old browser. I'm going to give that ago. My MD told me to take the second dose by noon. An important placebo effect was noted. So I have had the strangest symptom, probably for around a year now, possibly more. 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